Digoxin, HIF-1, and cancer
نویسندگان
چکیده
منابع مشابه
Digoxin, HIF-1, and cancer.
In a recent issue of PNAS, Zhang et al. (1) find that digoxin inhibits HIF-1 (a transcription factor highly involved in cancer development) and suggest that this effect might be observed in patients taking this drug. They also report that digoxin blocks tumor growth in mice (1). These data suggest that digoxin has anticancer potential. The authors observe that digoxin inhibits HIF-1 at 100 nM a...
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A library of drugs that are in clinical trials or use was screened for inhibitors of hypoxia-inducible factor 1 (HIF-1). Twenty drugs inhibited HIF-1-dependent gene transcription by >88% at a concentration of 0.4 microM. Eleven of these drugs were cardiac glycosides, including digoxin, ouabain, and proscillaridin A, which inhibited HIF-1alpha protein synthesis and expression of HIF-1 target gen...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2009
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.0813047106